Immunopathology of COVID 19

Even though Corona virus has responsive stimuli for ACE2-expressing epithelial cells of the respiratory tract, systemic hyperinflammation is the severe symptom in patients with COVID-19. Systemic inflammation causes vasodilation, and allows inflammatory lymphocytic and monocytic infiltration of the lung and the heart. In particular, pathogenic GM-CSF-secreting T-cells were shown to correspond with the employement of inflammatory IL-6-secreting monocytes and severe lung pathology in COVID-19 patients. Infiltrates of lymphocytes have also been reported at autopsy. Organs are mainly affected by an inflammatory response in patients with lethal COVID-19.

  • Systemic hyper inflammation
  • Vasodilation
  • Pneumonia

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